Xenograft Combined with a Mixture of Polynucleotides and Hyaluronic Acid (PN-HA) for Horizontal Alveolar Bone Regeneration: Clinical and Histologic Assessments in a Case Series.

This article investigates the clinical and histologic efficacy of a polynucleotide-hyaluronic acid (PN-HA) gel combined with deproteinized bovine bone mineral (DBBM) particles for horizontal alveolar bone regeneration in six adult patients. The graft mixture (DBBM:PN-HA in a 3:1 ratio) was covered with a resorbable collagen membrane and evaluated after 5 months, showing uneventful healing, well-vascularized and integrated regenerated bone, and an average horizontal bone gain of 4.91 ± 0.88 mm on CBCT scans. Histomorphometric analysis revealed that newly formed bone occupied 41.2% ± 12.4% of the samples, with residual biomaterial fully embedded and no significant inflammatory response. The study concludes that PN-HA mixed with DBBM is a safe and promising grafting material for horizontal alveolar bone augmentation, though further controlled trials are needed to optimize protocols and confirm these preliminary findings.