Evaluation of the relationship between testosterone level in patients with urethral stricture and its effect on outcome of surgery.

This article focuses on assessing the association between testosterone (T) levels and surgical outcomes in patients with urethral stricture (US) undergoing anastomotic urethroplasty. In a prospective study of 70 patients, lower free and total testosterone levels, along with diabetic status and wound infection, were significantly associated with higher rates of surgical failure, while preoperative post-void residual volume (PVR), maximum urinary flow rate (Q-max), and International Prostate Symptom Score (IPSS) did not predict outcomes. Free and total testosterone levels demonstrated high sensitivity and specificity in predicting surgical failure at defined cut-off values. The study suggests that testosterone levels may play a role in the success of urethroplasty in US patients, although it acknowledges limitations including a single-center design and lack of a control group.