JOURNAL ARTICLE

Indapamide interference in liquid chromatography-tandem mass spectrometry aldosterone assay.

  • Published In: Annals of Clinical Biochemistry, 2026, v. 63, n. 3. P. 277 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Frank, Amy R; Johnston, Susan 3 of 3

Abstract

This article focuses on the interference caused by the antihypertensive drug indapamide in the measurement of aldosterone using liquid chromatography-tandem mass spectrometry (LC-MS/MS) for screening primary aldosteronism (PA) via the aldosterone renin ratio (ARR). Indapamide overlaps with the aldosterone-d4 internal standard signal, leading to falsely elevated aldosterone concentrations and potentially unnecessary further clinical investigations. The interference was identified during routine testing following updated prescribing guidelines favoring indapamide, affecting about 4% of patient samples analyzed. The study highlights the importance of ongoing interference testing in clinical assays, especially considering changes in medication use among patients undergoing endocrine screening.

Additional Information

  • Source:Annals of Clinical Biochemistry. 2026/05, Vol. 63, Issue 3, p277
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2026
  • ISSN:0004-5632
  • DOI:10.1177/00045632251388531
  • Accession Number:193488075
  • Copyright Statement:Copyright of Annals of Clinical Biochemistry is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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