JOURNAL ARTICLE

Hepcidin/Ferritin Ratio in Patients with Beta Thalassemia. A Single-Center Experience.

  • Published In: QJM: An International Journal of Medicine, 2024, v. 117. P. ii342 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Andrawes, Nevine Gamal; Abdelkader, Salwa Mostafa; Yossef, Soha Raouf; Georgios, Lauris Malak Botros 3 of 3

Abstract

The article focuses on the evaluation of various biomarkers in pediatric hematologic and hepatic conditions. It reports that tumor necrosis factor-alpha (TNF-α) levels are significantly elevated in hemophilia patients with arthropathy compared to controls, while ferritin levels do not differ significantly. In beta-thalassemia syndromes, serum hepcidin and the hepcidin/ferritin ratio vary between beta-thalassemia major and intermedia, with higher hepcidin levels and lower ratios observed in more severe disease, correlating with transfusion needs. Additionally, serum autotaxin (ATX) levels are markedly increased in children with chronic liver disease and correlate positively with disease severity scores and fibrosis stages. These findings suggest potential roles for TNF-α, hepcidin/ferritin ratio, and autotaxin as biomarkers in managing these pediatric conditions.

Additional Information

  • Source:QJM: An International Journal of Medicine. 2024/10, Vol. 117, pii342
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2024
  • ISSN:1460-2725
  • DOI:10.1093/qjmed/hcae175.792
  • Accession Number:181636409
  • Copyright Statement:Copyright of QJM: An International Journal of Medicine is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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