JOURNAL ARTICLE

Nitrous Oxide‐Induced Subacute Combined Degeneration of Spinal Cord.

  • Published In: Neurology & Clinical Neuroscience, 2025, v. 13, n. 3. P. 221 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Aso, Yasuhiro; Masuda, Teruaki; Kimura, Noriyuki 3 of 3

Abstract

A Japanese man in his 50s presented with symptoms of dysstasia, numbness, gait disturbance, and dysuria, leading to a diagnosis of Nitrous Oxide-induced subacute combined degeneration of the spinal cord. The patient had a history of recreational nitrous oxide use, resulting in reduced vitamin B12 levels and elevated homocysteine levels. Treatment with mecobalamin injections and oral administration led to improved neurological manifestations, with a significant reduction in spinal cord abnormalities observed on MRI scans. The study highlights the importance of early diagnosis, intervention, and cessation of nitrous oxide abuse in managing this condition. [Extracted from the article]

Additional Information

  • Source:Neurology & Clinical Neuroscience. 2025/05, Vol. 13, Issue 3, p221
  • Document Type:Case Study
  • Subject Area:Health and Medicine
  • Publication Date:2025
  • ISSN:2049-4173
  • DOI:10.1111/ncn3.12881
  • Accession Number:184768563
  • Copyright Statement:Copyright of Neurology & Clinical Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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