JOURNAL ARTICLE

Drug-specific presentation and outcome of drug reaction with eosinophilia and systemic symptoms (DRESS) in children: a scoping review.

  • Published In: Clinical & Experimental Dermatology, 2025, v. 50, n. 2. P. 408 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: George-Hyslop, Frances St; Cherepacha, Nicole; Chugani, Bindiya; Alabdeen, Yousef; Sanchez-Espino, Luis Fernando; Mahood, Quenby; Sibbald, Cathryn; Verstegen, Ruud H J 3 of 3

Abstract

This article focuses on drug-specific clinical features and outcomes of drug reaction with eosinophilia and systemic symptoms (DRESS) in children. A scoping review of 644 pediatric DRESS cases identified six drugs with sufficient data for analysis: carbamazepine, dapsone, lamotrigine, phenobarbital, phenytoin, and trimethoprim–sulfamethoxazole. The study found that dapsone-induced DRESS was associated with more severe disease, including increased organ involvement, highest mortality rate, and longest hospitalization, while trimethoprim–sulfamethoxazole was linked to a higher incidence of autoimmune sequelae. These findings suggest that the causative drug influences the clinical presentation and long-term management of pediatric DRESS, highlighting the importance of drug-specific considerations in diagnosis and treatment.

Additional Information

  • Source:Clinical & Experimental Dermatology. 2025/02, Vol. 50, Issue 2, p408
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2025
  • ISSN:0307-6938
  • DOI:10.1093/ced/llae418
  • Accession Number:182905067
  • Copyright Statement:Copyright of Clinical & Experimental Dermatology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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