JOURNAL ARTICLE

Genes encoding a novel thermostable bacteriocin in the thermophilic bacterium Aeribacillus pallidus PI8.

  • Published In: Journal of Applied Microbiology, 2023, v. 134, n. 12. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Kita, Kyosuke; Yoshida, Sanako; Masuo, Shunsuke; Nakamura, Akira; Ishikawa, Shu; Yoshida, Ken-ichi 3 of 3

Abstract

This article focuses on the identification and characterization of pallidocyclin, a novel thermostable circular bacteriocin produced by the Gram-positive thermophilic bacterium Aeribacillus pallidus PI8. The bacteriocin precursor is encoded by the gene pcynA within the pcynBACDEF operon, which is necessary and sufficient for pallidocyclin biosynthesis, as demonstrated by heterologous expression in Bacillus subtilis. The study also identifies pcynF as encoding a dedicated immunity protein that confers resistance to pallidocyclin in susceptible bacteria such as Geobacillus kaustophilus HTA426. Pallidocyclin exhibits antimicrobial activity against several thermophilic Gram-positive bacteria, including genera associated with food contamination, suggesting potential applications in controlling bacterial contaminants in industrial settings.

Additional Information

  • Source:Journal of Applied Microbiology. 2023/12, Vol. 134, Issue 12, p1
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2023
  • ISSN:1364-5072
  • DOI:10.1093/jambio/lxad293
  • Accession Number:174980242
  • Copyright Statement:Copyright of Journal of Applied Microbiology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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