Using MRgRT to Increase Tumor and Limit OAR Doses in Pancreatic Cancer Treatment.

This case study focuses on the use of magnetic resonance–guided radiation therapy (MRgRT) in treating an 87-year-old patient with newly diagnosed stage IIB pancreatic adenocarcinoma who declined surgery and chemotherapy. MRgRT combines magnetic resonance imaging with a linear accelerator to deliver precise, adaptive stereotactic body radiation therapy (SBRT), allowing higher radiation doses to the tumor while sparing nearby organs at risk (OAR). Over five treatment sessions, the patient tolerated the therapy well, demonstrated full participation despite advanced age and physical challenges, and showed no tumor progression or metastatic disease at a two-year follow-up, maintaining a good quality of life. The study highlights MRgRT as a promising definitive treatment option for pancreatic cancer, especially for patients who are ineligible or unwilling to undergo conventional therapies.