JOURNAL ARTICLE

Occupational exposure to arsenic and leukopenia risk: Toxicological alert.

  • Published In: Toxicology & Industrial Health, 2024, v. 40, n. 12. P. 637 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Bidu, Nadielle Silva; Lemos, Diogo Sousa; Fernandes, Bruno José Dumêt 3 of 3

Abstract

This article focuses on the risk of leukopenia in workers occupationally exposed to inorganic arsenic, primarily through inhalation in industries such as mining, smelting, and chemical manufacturing. It highlights arsenic's toxic effects on the hematopoietic system, including inhibition of erythropoiesis linked to the regulatory factor GATA-1 and disruption of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway, which is crucial for immune and blood cell development. The article also discusses arsenic's absorption, metabolism, and systemic toxicity, emphasizing that workplace exposure limits are set by agencies like OSHA and NIOSH to mitigate health risks. It concludes that monitoring tissue arsenic levels in hair and nails is a preferred method for assessing exposure in suspected cases of arsenic toxicity.

Additional Information

  • Source:Toxicology & Industrial Health. 2024/12, Vol. 40, Issue 12, p637
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2024
  • ISSN:0748-2337
  • DOI:10.1177/07482337241277261
  • Accession Number:180167337
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