JOURNAL ARTICLE

P12 Tetrapeptide matrikines synchronize circadian rhythms and promote proliferation in human skin cells.

  • Published In: British Journal of Dermatology, 2023, v. 189, n. 1. P. e18 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: El-Houni, Zeyad; Eckersley, Alexander; Bell, Mike; Bradley, Eleanor; Newton, Victoria; Sherratt, Michael; Meng, Qing Jun 3 of 3

Abstract

This article focuses on the effects of two novel tetrapeptides, GPKG and LSVD, on the circadian rhythms of skin cells. Circadian rhythms are intrinsic 24-hour cycles that regulate skin adaptation to external stimuli and are known to be impaired in aging skin. Using HaCat keratinocytes with a Per2::luc reporter, the study found that both peptides significantly enhanced circadian oscillatory activity and increased cell proliferation at higher concentrations. These findings suggest that GPKG and LSVD may improve skin cell function by synchronizing their circadian clocks, offering potential therapeutic avenues for age-related and disease-associated circadian disruptions in skin.

Additional Information

  • Source:British Journal of Dermatology. 2023/07, Vol. 189, Issue 1, pe18
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2023
  • ISSN:0007-0963
  • DOI:10.1093/bjd/ljad174.033
  • Accession Number:169875813
  • Copyright Statement:Copyright of British Journal of Dermatology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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