Outcomes of High-Risk Breast MRI Screening in Women Without Prior History of Breast Cancer: Effectiveness Data from a Tertiary Care Center.

This article evaluates the diagnostic performance of a breast magnetic resonance imaging (MRI) screening program in 681 asymptomatic women at high risk for breast cancer without a prior history of the disease. The retrospective cohort study of 1,405 screening breast MRIs conducted from 2015 to 2019 found a cancer detection rate of 20 per 1,000 examinations, with a sensitivity of 93.3%, specificity of 83.4%, and a false-negative rate of 0.1%. Most detected cancers (92.9%) were early stage (stage 0 or 1) and node negative (89.3%), particularly in incidence round screenings performed within 18 months of a prior MRI. The findings support the effectiveness of annual breast MRI screening in this high-risk population for early detection of small, node-negative breast cancers with favorable outcomes.