JOURNAL ARTICLE

Effect of vitamin E δ-tocotrienol and aspirin on Wnt signaling in human colon cancer stem cells and in adenoma development in APCmin/+ mice.

  • Published In: Carcinogenesis, 2024, v. 45, n. 12. P. 881 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Husain, Kazim; Coppola, Domenico; Yang, Chung S; Malafa, Mokenge P 3 of 3

Abstract

This article focuses on the combined effects of vitamin E δ-tocotrienol (DT3) and aspirin on Wnt/β-catenin signaling and apoptosis in human colon cancer stem cells (CCSCs) and adenoma formation in APC^min/+ mice, a model for colorectal cancer (CRC). The study demonstrates that aspirin and DT3 together inhibit cell growth, suppress Wnt/β-catenin pathway activity, reduce expression of downstream oncogenic targets (c-MYC, cyclin D1, survivin), and induce apoptosis via the caspase 8/BID/BAX pathway in CCSCs and APC-deficient colon epithelial cells, with minimal effects on normal cells. In vivo, this combination significantly reduced intestinal adenoma formation and enhanced apoptotic signaling in APC^min/+ mice compared to either agent alone. These findings suggest that aspirin combined with DT3 holds potential as a chemopreventive strategy against colorectal tumorigenesis by targeting cancer stem cell survival and Wnt/β-catenin signaling.

Additional Information

  • Source:Carcinogenesis. 2024/12, Vol. 45, Issue 12, p881
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2024
  • ISSN:0143-3334
  • DOI:10.1093/carcin/bgae041
  • Accession Number:181970180
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