JOURNAL ARTICLE

Malignant Para-Testicular Mesothelioma: A Rare Presentation in the Tunica Vaginalis of an Elderly Male With No Prior Asbestos Exposure.

  • Published In: International Journal of Surgical Pathology, 2024, v. 32, n. 6. P. 1117 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Shaker, Nada; Blankenship, Heath; Shaker, Nuha; Ben Musa, Ruwaida; Niu, Shuo; Alrohaibani, Alaaeddin; Mansoor, Ibrahim; Abu Shakra, Rafat; Sangueza, Omar P. 3 of 3

Abstract

This article focuses on malignant mesothelioma of the tunica vaginalis, a rare and aggressive tumor arising from the mesothelial cells lining the tunica vaginalis in elderly male patients. Diagnosis relies heavily on histopathological examination and immunohistochemical staining with markers such as WT1, D2-40, and calretinin to distinguish it from other para-testicular tumors. The standard treatment is orchidectomy, which can be curative in localized cases, while advanced disease may require additional therapies including chemotherapy and radiation. Molecular alterations, including mutations in genes like BAP1 and NF2, are implicated in tumor development and may inform future targeted therapies. Prognosis depends on factors such as tumor differentiation, size, and metastasis at presentation.

Additional Information

  • Source:International Journal of Surgical Pathology. 2024/09, Vol. 32, Issue 6, p1117
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2024
  • ISSN:1066-8969
  • DOI:10.1177/10668969231215426
  • Accession Number:179146033
  • Copyright Statement:Copyright of International Journal of Surgical Pathology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Looking to go deeper into this topic? Look for more articles on EBSCOhost.