JOURNAL ARTICLE

P04 How fibroblasts and azathioprine prepare the soil for cutaneous squamous cell carcinoma.

  • Published In: British Journal of Dermatology, 2024, v. 190, n. 6. P. e80 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Kontou, Ioanna; Pourzand, Charareh; Walko, Gernot; Jungwirth, Ute 3 of 3

Abstract

This article focuses on the combined effects of azathioprine (AZA), an immunosuppressive drug, and ultraviolet A (UVA) radiation on human dermal fibroblasts and their role in cutaneous squamous cell carcinoma (cSCC) development. The study demonstrates that AZA and UVA synergistically reduce the viability of both neonatal (UV-naïve) and adult (sun-exposed) fibroblasts while increasing fibroblast senescence. These senescent fibroblasts may alter their secretome, influencing the growth and stem cell-like properties of premalignant and malignant keratinocytes in cSCC. Using three-dimensional co-culture models, the research highlights how AZA/UVA exposure in the tumor microenvironment could promote cSCC initiation and progression.

Additional Information

  • Source:British Journal of Dermatology. 2024/06, Vol. 190, Issue 6, pe80
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2024
  • ISSN:0007-0963
  • DOI:10.1093/bjd/ljae105.026
  • Accession Number:177358773
  • Copyright Statement:Copyright of British Journal of Dermatology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Looking to go deeper into this topic? Look for more articles on EBSCOhost.