JOURNAL ARTICLE

Yes, the human brain has around 86 billion neurons.

  • Published In: Brain: A Journal of Neurology, 2025, v. 148, n. 5. P. e37 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Lent, Roberto 3 of 3

Abstract

This article focuses on the scientific debate surrounding the estimated number of neurons in the human brain, challenging the traditionally cited figure of 100 billion neurons. It describes the development and application of the isotropic fractionator technique, which provided evidence for a lower estimate of about 86 billion neurons, roughly 15% less than the previous number, and revealed that glial cells are approximately as numerous as neurons. The author addresses criticisms regarding sample size and methodological limitations, emphasizing the complexities of post-mortem human brain research and the importance of using specific and universal cellular markers. The article argues for the relevance of accurately estimating brain cellularity to understand developmental changes, disease impacts, and future in vivo predictions, recommending cautious use of neuron number estimates in scientific discourse.

Additional Information

  • Source:Brain: A Journal of Neurology. 2025/05, Vol. 148, Issue 5, pe37
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2025
  • ISSN:0006-8950
  • DOI:10.1093/brain/awaf048
  • Accession Number:185679070

Looking to go deeper into this topic? Look for more articles on EBSCOhost.