JOURNAL ARTICLE

CD48 suppresses proliferation and migration as an immune-related prognostic signature in the cervical cancer immune microenvironment.

  • Published In: Carcinogenesis, 2024, v. 45, n. 1/2. P. 57 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Ma, Yue; Yang, Zhuo; Liu, Jing; Wang, Danbo 3 of 3

Abstract

This article focuses on identifying immune-related molecular targets associated with cervical cancer (CC) progression and prognosis through gene co-expression network analysis and immune cell infiltration assessment. Using data from the GEO and The Cancer Genome Atlas (TCGA) databases, five candidate hub genes—CD2, CD3D, CD48, CSF2RB, and CXCR6—were found to correlate with T cell infiltration and patient survival. Among these, CD48 was notably downregulated in CC tissues and negatively associated with advanced clinical stage, lymph node metastasis, and poor differentiation; functional experiments demonstrated that CD48 suppresses CC cell proliferation, migration, and tumor growth. These findings suggest CD48 as a potential immune-related prognostic biomarker and therapeutic target, providing insights for the development of molecular and immunotherapies against cervical cancer.

Additional Information

  • Source:Carcinogenesis. 2024/01, Vol. 45, Issue 1/2, p57
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2024
  • ISSN:0143-3334
  • DOI:10.1093/carcin/bgad039
  • Accession Number:175416629
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