JOURNAL ARTICLE

Anti-Pythium insidiosum activity of bioactive compounds from medicinal plants.

  • Published In: Letters in Applied Microbiology, 2023, v. 76, n. 1. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Silveira, Júlia de Souza; Braga, Caroline Quintana; Bermann, Carolina dos Santos; Ianiski, Lara Baccarin; Bruhn, Fábio Raphael Pascoti; Botton, Sônia de Avila; Pereira, Daniela Isabel Brayer 3 of 3

Abstract

This article focuses on evaluating the in vitro susceptibility of the aquatic oomycete *Pythium insidiosum*, the causative agent of pythiosis in mammals, to certain bioactive compounds and their respective essential oils. The study tested eugenol, α-terpineol, menthol, and carvacrol—major components of the essential oils from *Eugenia caryophyllata*, *Melaleuca alternifolia*, *Mentha piperita*, and *Origanum vulgare*, respectively—against 34 isolates of *P. insidiosum*. Results showed that α-terpineol, carvacrol, and eugenol exhibited stronger anti-*P. insidiosum* activity than their source essential oils, with α-terpineol demonstrating the highest inhibitory effect, while menthol's activity was comparable to its essential oil. These findings suggest that essential oils and their major bioactive compounds hold potential as alternative treatments for pythiosis, a disease with limited responsiveness to conventional antifungal drugs due to the pathogen's unique cell membrane composition.

Additional Information

  • Source:Letters in Applied Microbiology. 2023/01, Vol. 76, Issue 1, p1
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2023
  • ISSN:0266-8254
  • DOI:10.1093/lambio/ovac019
  • Accession Number:162330180
  • Copyright Statement:Copyright of Letters in Applied Microbiology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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