Stachys byzantina K. Koch (Lamiaceae) as a potential ingredient for delaying skin ageing and treating hyperpigmentation disorders in pharmaceutical products.

This article investigates the potential of Stachys byzantina, a plant species, as a source of bioactive compounds for delaying skin ageing and treating hyperpigmentation. The study found that the dichloromethane fraction (DF) of the ethanolic extract from the plant’s aerial parts effectively inhibited key enzymes involved in skin ageing and pigmentation, including tyrosinase, hyaluronidase, and elastase, while also demonstrating significant antioxidant, antiglycation, and sun protection factor (SPF) activities without cytotoxicity to skin cells at concentrations below 50 μg/ml. Chemical analyses identified chlorogenic acid and verbascoside as major constituents likely responsible for these bioactivities. These findings suggest that S. byzantina DF has promising applications as a cosmetic or therapeutic ingredient for skin health, warranting further research and development.