JOURNAL ARTICLE

University of Science and Technology of China Researchers Further Understanding of Autism (Large-scale EM data reveals myelinated axonal changes and altered connectivity in the corpus callosum of an autism mouse model).

  • Published In: Mental Health Weekly Digest, 2025. P. 1633 1 of 2

  • Database: Psychology Source 2 of 2

Abstract

The article focuses on a study investigating structural abnormalities in the corpus callosum related to autism spectrum disorder (ASD). Conducted by researchers at the University of Science and Technology of China, the study utilized serial scanning electron microscopy to analyze myelinated axon properties in both wild-type and Shank3B mutant mice. Findings revealed increased myelinated axon density and thinner myelin sheaths in the autism model, suggesting that myelination deficits may contribute to communication impairments between brain hemispheres in ASD. The researchers emphasize the need for further studies to connect these morphological changes with functional neural dysfunction in ASD. [Extracted from the article]

Additional Information

  • Source:Mental Health Weekly Digest. 2025/05, p1633
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2025
  • ISSN:1543-6616
  • Accession Number:184722758
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