JOURNAL ARTICLE

Prevalence and predictors of Barrett's esophagus and esophageal cancer in patients with eosinophilic esophagitis.

  • Published In: Diseases of the Esophagus, 2025, v. 38, n. 1. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Zhou, Margaret J; Hsing, Ann W; Clarke, John O 3 of 3

Abstract

This article examines the risk of Barrett's esophagus (BE) and esophageal cancer (EC) in patients with eosinophilic esophagitis (EoE), an immune-mediated esophageal condition, using data from the US Merative MarketScan® Research Database. Among nearly 3 million adults undergoing first-time upper endoscopy between 2008 and 2020, the prevalence and incidence of BE and EC were found to be comparable between patients with and without EoE. Established risk factors for BE and EC in the general population—such as older age, male sex, hiatal hernia, and gastroesophageal reflux disease (GERD)—also predicted BE and EC in patients with EoE. The findings support current clinical understanding that EoE does not increase the risk of BE or EC, indicating that standard BE screening guidelines remain appropriate for patients with EoE.

Additional Information

  • Source:Diseases of the Esophagus. 2025/02, Vol. 38, Issue 1, p1
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2025
  • ISSN:1120-8694
  • DOI:10.1093/dote/doae120
  • Accession Number:183431131
  • Copyright Statement:Copyright of Diseases of the Esophagus is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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