JOURNAL ARTICLE

Adult Drosophila aversion to caffeine requires a unique TrpA1 isoform and the PLC signaling cascade.

  • Published In: Chemical Senses, 2025, v. 50. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Milleville, Romane; Gillas, Jade; La, Amanda-Thuy; Manière, Gérard; Berthelot-Grosjean, Martine; Grosjean, Yael; Royet, Julien; Kurz, Cyril Leopold 3 of 3

Abstract

The article focuses on the role of the transient receptor potential channel TrpA1, specifically its E isoform, in mediating caffeine-induced aversion in the fruit fly *Drosophila melanogaster*. Taste neurons expressing the bitter receptor Gr66a detect caffeine, and the TrpA1-E isoform within these neurons is essential for suppressing the proboscis extension reflex (PER) when caffeine is mixed with sucrose. This aversive response requires TrpA1 activity and intracellular signaling involving phospholipase C (PLC) and the inositol trisphosphate receptor (IP3R) in adult Gr66a+ neurons. The study demonstrates that TrpA1-E+ cells in the proboscis directly respond to caffeine, integrating gustatory receptor signaling with TrpA1-mediated pathways to regulate feeding behavior.

Additional Information

  • Source:Chemical Senses. 2025/01, Vol. 50, p1
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2025
  • ISSN:0379-864X
  • DOI:10.1093/chemse/bjaf058
  • Accession Number:192513348
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