JOURNAL ARTICLE

B - 92 Poor Olfaction Prior to Cardiac Surgery: Associations with Cognition, Plasma Neurofilament Light and Postoperative Delirium in a Prospective Nested Cohort Study.

  • Published In: Archives of Clinical Neuropsychology, 2023, v. 38, n. 7. P. 1459 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Le, Lan M; Yanek, Lisa; Neufeld, Karin J; Moghekar, Abhay; Hogue, Charles; Brown, Charles H; Kamath, Vidyulata 3 of 3

Abstract

This article focuses on the association between preoperative olfactory function and postoperative delirium in individuals undergoing cardiac surgery. In a prospective cohort of 189 patients (mean age 70 years, 75% men), impaired olfaction measured by the 12-item Brief Smell Identification Test (BSIT) was linked to higher incidence and severity of delirium, as assessed by the Confusion Assessment Method (CAM) and Delirium Rating Scale-Revised-1998 (DRS-R-98). Additionally, poorer baseline olfaction correlated with cognitive impairment and elevated plasma neurofilament light (NfL) levels, a biomarker measured by the Simoa™ NF-Light Assay. The findings suggest that preoperative olfactory testing may help identify brain vulnerability and stratify risk for postoperative delirium in cardiac surgery patients.

Additional Information

  • Source:Archives of Clinical Neuropsychology. 2023/10, Vol. 38, Issue 7, p1459
  • Document Type:Abstract
  • Subject Area:Health and Medicine
  • Publication Date:2023
  • ISSN:0887-6177
  • DOI:10.1093/arclin/acad067.298
  • Accession Number:174275076
  • Copyright Statement:Copyright of Archives of Clinical Neuropsychology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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