JOURNAL ARTICLE

MiRNA-21-5p induces chicken hepatic lipogenesis by targeting NFIB and KLF3 to suppress the PI3K/AKT signaling pathway.

  • Published In: Journal of Animal Science, 2024, v. 102. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Wu, Yamei; Zhao, Jing; Cui, Can; Zhang, Yao; Zhu, Qing; Han, Shunshun; Yang, Chaowu; Yin, Huadong 3 of 3

Abstract

This article investigates the role of microRNA-21-5p (miR-21-5p) in regulating liver metabolism and fatty liver syndrome (FLS) in chickens. The study demonstrates that miR-21-5p is upregulated in fatty chicken livers and promotes hepatocyte lipogenesis, oxidative stress, inflammation, and apoptosis by directly targeting the nuclear factor I B (NFIB) and kruppel-like factor 3 (KLF3) genes. These interactions suppress the PI3K/AKT signaling pathway, which is involved in cellular metabolism and survival. The findings provide insights into the molecular mechanisms underlying FLS in poultry and suggest potential targets for improving liver health and production outcomes in chickens.

Additional Information

  • Source:Journal of Animal Science. 2024/01, Vol. 102, p1
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2024
  • ISSN:0021-8812
  • DOI:10.1093/jas/skae055
  • Accession Number:182431626
  • Copyright Statement:Copyright of Journal of Animal Science is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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