Did the creeping vole sex chromosomes evolve through a cascade of adaptive responses to a selfish x chromosome?

  • Published In: BioEssays, 2023, v. 45, n. 12. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Roy, Scott William 3 of 3

Abstract

The creeping vole Microtus oregoni exhibits remarkably transformed sex chromosome biology, with complete chromosome drive/drag, X‐Y fusions, sex reversed X complements, biased X inactivation, and X chromosome degradation. Beginning with a selfish X chromosome, I propose a series of adaptations leading to this system, each compensating for deleterious consequences of the preceding adaptation: (1) YY embryonic inviability favored evolution of a selfish feminizing X chromosome; (2) the consequent Y chromosome transmission disadvantage favored X‐Y fusion ("XP"); (3) Xist‐based silencing of Y‐derived XP genes favored a second X‐Y fusion ("XM"); (4) X chromosome dosage‐related costs in XPXM males favored the evolution of XM loss during spermatogenesis; (5) X chromosomal dosage‐related costs in XM0 females favored the evolution of XM drive during oogenesis; and (6) degradation of the non‐recombining XP favored the evolution of biased X chromosome inactivation. I discuss recurrent rodent sex chromosome transformation, and selfish genes as a constructive force in evolution. [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:BioEssays. 2023/12, Vol. 45, Issue 12, p1
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2023
  • ISSN:0265-9247
  • DOI:10.1002/bies.202100164
  • Accession Number:173760226
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