Magnetic Resonance Imaging T2* Study of Pancreatic and Tissue Iron Overload and Glucose Dysregulation in Young Children with Transfusion Dependent Thalassemia.

The article presents multiple pediatric clinical studies focusing on distinct medical conditions. One study assessed serum brain-specific (anti-MOG) and systemic (ANA) antibodies in 25 autistic children compared to healthy controls, finding no significant difference in antibody levels between groups. Another study evaluated cardiac involvement in 72 pediatric COVID-19 patients, identifying that those with cardiac affection exhibited higher inflammatory markers and reduced ejection fraction. A third study used Magnetic Resonance Imaging T2* to measure pancreatic, cardiac, and hepatic iron overload in 50 children with transfusion-dependent thalassemia, revealing correlations between pancreatic and liver iron load with glucose dysregulation and insulin resistance. Lastly, a cross-sectional study of 35 pediatric patients with chronic kidney disease stage 5 on hemodialysis documented high prevalence of dermatological manifestations such as xerosis and pruritis. These studies collectively contribute to understanding immunological, cardiac, metabolic, and dermatological aspects in pediatric populations with chronic or acute illnesses.