JOURNAL ARTICLE

Assessment of drug-drug interactions among patients with hematologic malignancy: A clinical pharmacist-led study.

  • Published In: Journal of Oncology Pharmacy Practice, 2025, v. 31, n. 8. P. 1256 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Zarrabi, Sogol; Hosseini, Elham; Sadeghi, Kourosh; Vaezi, Mohammad; Shahrami, Bita 3 of 3

Abstract

This article focuses on the identification, characterization, and management of drug-drug interactions (DDIs) in hospitalized patients with hematologic malignancies. In a prospective interventional study of 200 patients receiving at least four concurrent medications, 1,281 potential DDIs were identified using Lexi-interact® and Micromedex® databases, with over half classified as major severity and primarily pharmacokinetic in mechanism. Clinical pharmacists evaluated these DDIs, deeming 81.1% clinically significant and implementing 1,059 pharmacotherapy interventions, mainly involving therapy monitoring. The study found a strong positive correlation between the number of medications administered and the occurrence of DDIs, underscoring the critical role of clinical pharmacists in assessing and managing DDIs to enhance patient safety in hematology care.

Additional Information

  • Source:Journal of Oncology Pharmacy Practice. 2025/12, Vol. 31, Issue 8, p1256
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2025
  • ISSN:1078-1552
  • DOI:10.1177/10781552241281664
  • Accession Number:189287395
  • Copyright Statement:Copyright of Journal of Oncology Pharmacy Practice is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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