JOURNAL ARTICLE

Doxorubicin-induced sweet taste sensitivity reduction and compensatory receptor expression in mice.

  • Published In: Chemical Senses, 2025, v. 50. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Mogi, Keisuke; Azuma, Misaki; Iwaki, Shiori; Matsuda, Yuka; Morito, Katsuya; Takayama, Kentaro; Nagasawa, Kazuki 3 of 3

Abstract

This article focuses on the effects of doxorubicin (DOX), a widely used anticancer anthracycline, on taste responsiveness in mice. The study found that DOX administration reversibly decreased sweet taste sensitivity by day 7 without affecting responsiveness to umami, bitter, salty, or sour tastes. Despite no detectable changes in the morphology or number of taste buds in the circumvallate papillae (CP), mRNA expression of sweet taste receptors (T1R2, T1R3) and α-gustducin was increased, suggesting a compensatory response to reduced sweet taste signaling and decreased energy intake. These findings provide insight into the mechanisms underlying DOX-induced taste disorders, which may inform strategies to maintain quality of life and nutritional status in patients undergoing chemotherapy.

Additional Information

  • Source:Chemical Senses. 2025/01, Vol. 50, p1
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2025
  • ISSN:0379-864X
  • DOI:10.1093/chemse/bjaf011
  • Accession Number:192513301
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