JOURNAL ARTICLE

Pharmacodynamic assessment of apramycin against Mycobacterium abscessus in a hollow fibre infection model.

  • Published In: Journal of Antimicrobial Chemotherapy (JAC), 2025, v. 80, n. 5. P. 1309 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Singh, Nidhi; Dangi, Bikash; Johnson, Jeremy J; Louie, Arnold; Karunanidhi, Arunkumar; Curry, Brooke N; Mitarai, Satoshi; Daley, Charles L; Hobbie, Sven N; Bulman, Zackery P 3 of 3

Abstract

This article focuses on evaluating the pharmacodynamic activity of apramycin, an aminoglycoside antibiotic, against Mycobacterium abscessus, a significant cause of pulmonary infections especially in people with cystic fibrosis. Using a 14-day hollow fibre infection model simulating human epithelial lining fluid concentrations, apramycin demonstrated greater bacterial killing than amikacin against two M. abscessus subsp. abscessus isolates with median susceptibility profiles. However, resistance to apramycin emerged during monotherapy, indicating that combination antibiotic strategies may be necessary to prevent resistance development. These findings suggest apramycin is a promising candidate for treating M. abscessus pulmonary infections, but further studies are needed to optimize dosing and assess combination therapies.

Additional Information

  • Source:Journal of Antimicrobial Chemotherapy (JAC). 2025/05, Vol. 80, Issue 5, p1309
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2025
  • ISSN:0305-7453
  • DOI:10.1093/jac/dkaf073
  • Accession Number:185320616
  • Copyright Statement:Copyright of Journal of Antimicrobial Chemotherapy (JAC) is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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