An Animal Model of Bone Grafting Procedure for Anterior Shoulder Instability and Strategies for Accelerating Graft Healing.

This article focuses on establishing a rabbit model of anterior shoulder instability to evaluate the effects of a modified inlay bone grafting procedure and postoperative administration of parathyroid hormone 1-34 (PTH1-34) on graft healing. The modified inlay technique, which involves creating a groove on the glenoid to fit the graft, was found to enhance early osteogenic activity, accelerate graft integration, and promote faster callus maturation compared to the conventional onlay procedure. Additionally, intermittent subcutaneous injections of PTH1-34 after surgery further increased new bone formation, osteogenic markers, and shortened healing time in both surgical methods. These findings suggest that combining the inlay grafting technique with PTH1-34 administration may improve clinical outcomes in bone grafting treatments for anterior shoulder instability.