JOURNAL ARTICLE

Effects of the genetic variants of alcohol-metabolizing enzymes on lipid levels in Asian populations: a systematic review and meta-analysis.

  • Published In: Nutrition Reviews, 2023, v. 81, n. 8. P. 921 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Luo, Zhi; Cheng, Jun; Wang, Yanggan 3 of 3

Abstract

This article systematically examines the effects of two genetic variants—rs671 in the ALDH2 gene (aldehyde dehydrogenase 2) and rs1229984 in the ADH2 gene (alcohol dehydrogenase 2)—on lipid metabolism and alcohol intake in East Asian populations, including Japanese, Chinese, and Korean individuals. Meta-analyses of 86 studies involving 179,640 participants found that the rs671 A allele is associated with increased low-density lipoprotein cholesterol (LDL-C) and decreased triglycerides and high-density lipoprotein cholesterol (HDL-C), while the rs1229984 A allele is linked to decreased LDL-C levels. The influence of these variants on lipid levels was stronger in Japanese individuals and males, with alcohol intake modulating lipid profiles particularly in Japanese males carrying the rs671 variant. These findings suggest that rs671 and rs1229984 may serve as genetic markers for lipid dyslipidemia and coronary artery disease risk in East Asian populations, with implications for personalized risk assessment related to alcohol metabolism.

Additional Information

  • Source:Nutrition Reviews. 2023/08, Vol. 81, Issue 8, p921
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2023
  • ISSN:0029-6643
  • DOI:10.1093/nutrit/nuac100
  • Accession Number:164879978
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