JOURNAL ARTICLE

miRNA-23a modulates sodium-hydrogen exchanger 1 expression: studies in medullary thick ascending limb of salt-induced hypertensive rats.

  • Published In: Nephrology Dialysis Transplantation, 2023, v. 38, n. 3. P. 586 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Lombari, Patrizia; Mallardo, Massimo; Petrazzuolo, Oriana; Nagoth, Joseph Amruthraj; Fiume, Giuseppe; Scanni, Roberto; Iervolino, Anna; Damiano, Sara; Coppola, Annapaola; Borriello, Margherita; Ingrosso, Diego; Perna, Alessandra F; Zacchia, Miriam; Trepiccione, Francesco; Capasso, Giovambattista 3 of 3

Abstract

This article investigates the role of microRNA-23a (miRNA-23a) in regulating the sodium-hydrogen exchanger 1 (NHE1) in the medullary thick ascending limb (mTAL) of the nephron under conditions of high sodium intake, which is relevant to essential hypertension. Using a rat model of salt-sensitive hypertension, the study found that high sodium intake leads to downregulation of miRNA-23a and a corresponding upregulation of NHE1 protein in the mTAL, without changes at the mRNA level, suggesting post-transcriptional regulation. In vitro experiments confirmed that overexpression of miRNA-23a reduces NHE1 protein abundance in rat mTAL cells. These findings highlight miRNA-23a as a potential regulator of NHE1 and acid–base balance in the kidney, contributing to the pathophysiology of salt-sensitive hypertension.

Additional Information

  • Source:Nephrology Dialysis Transplantation. 2023/03, Vol. 38, Issue 3, p586
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2023
  • ISSN:0931-0509
  • DOI:10.1093/ndt/gfac232
  • Accession Number:162130592
  • Copyright Statement:Copyright of Nephrology Dialysis Transplantation is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Looking to go deeper into this topic? Look for more articles on EBSCOhost.