JOURNAL ARTICLE

An Investigative Review for Pharmaceutical Analysis of Fenofibrate.

  • Published In: Journal of Chromatographic Science, 2023, v. 61, n. 5. P. 494 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Saha, Moumita; Dhiman, Shubham; Gupta, G D; Asati, Vivek 3 of 3

Abstract

This article focuses on the analytical methodologies used for the pharmaceutical analysis of fenofibrate (FEN), a second-generation fibric acid prodrug and lipoprotein lipase activator that acts as a peroxisome proliferator activated receptor α (PPARα) agonist to reduce lipid levels. It reviews various chromatographic and non-chromatographic techniques for identifying and quantifying FEN in pure forms, pharmaceuticals, and biological samples, highlighting high-performance liquid chromatography (HPLC) and UV/vis-spectrophotometry as the most commonly employed methods. The article also notes that while numerous HPLC methods exist for FEN analysis, studies using capillary electrophoresis and high-performance thin-layer chromatography (HPTLC) are limited, and only a few methods address pharmacokinetics and bioequivalence in human plasma. This comprehensive summary of analytical approaches aims to support researchers and analysts in quality control and drug analysis related to fenofibrate.

Additional Information

  • Source:Journal of Chromatographic Science. 2023/05, Vol. 61, Issue 5, p494
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2023
  • ISSN:0021-9665
  • DOI:10.1093/chromsci/bmac072
  • Accession Number:164066623
  • Copyright Statement:Copyright of Journal of Chromatographic Science is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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