Impact of Glucosinolates Intervention in Controlling the Progression of Cancer: A Systematic Review of a Randomized Controlled Trial.

Introduction: Glucosinolates (GSLs) are sulfur and nitrogen-containing compounds in the Brassicaceae family of eudicots, such as mustard, broccoli and cabbage. GSLs are potent secondary metabolites that protect plants against environmental stressors, particularly herbivores and pathogens. In recent years, increasing attention has been directed towards the potential of bioactive compounds derived from natural sources as adjunctive strategies in cancer prevention and control. GSLs have emerged as promising candidates due to their physiological effects and anticancer properties. Objective: This systematic review aims to explain the significance of GSLs and their derivatives intervention on cancer progression through a systematic review of randomized controlled trials (RCTs). Materials and methods: Four electronic databases were used in this study: PubMed, Scopus, Web of Science (WoS) and Science Direct. Twenty-one RCTs were selected based on several inclusion and exclusion criteria. Selection of the studies, data extraction, and quality evaluation were carried out separately by two reviewers. Results: The contribution to the current knowledge on the effectiveness of GSLs in controlling cancer progression and prevention is highlighted from the analysis of the selected 21 clinical trial articles. These trials were conducted using GSLs as a single agent or combined with other therapeutic agents against various cancers. Aliphatic GSLs, indolic GSLs and isothiocyanate derivatives are used as interventions in the studies. Conclusion: This review supports the need for more studies on the pharmacological and biological properties of GSLs in different types of cancer to be conducted to understand how GSLs can help in controlling the progression of cancer towards its prevention. [ABSTRACT FROM AUTHOR]