Impact of subgingival instrumentation on systemic inflammation and serum bone resorption marker in premenopausal women with periodontitis: a prospective interventional study.

This article investigates the impact of subgingival instrumentation (SI), a nonsurgical periodontal therapy, on systemic inflammation and bone resorption in systemically healthy premenopausal women with stage II and III periodontitis. The study found that SI significantly reduced serum interleukin 6 (IL-6), a marker of systemic inflammation, and serum C-terminal telopeptide of type I collagen (CTX), a marker of bone resorption, eight weeks post-treatment. Additionally, improvements in periodontal parameters and decreases in eosinophil count and mean platelet volume were observed, while other hematologic parameters remained unchanged. These findings suggest that controlling periodontal inflammation through SI may positively influence systemic inflammatory status and bone metabolism, highlighting a potential role for periodontal treatment in supporting bone health.