Bioactive Glass in a Multi Drug Resistance Osteomyelitis in Diabetic Foot: Case Report.

This article focuses on the challenges and emerging treatments for diabetic foot osteomyelitis (DFO), particularly in cases involving multidrug-resistant organisms (MDRO). It highlights the limitations of prolonged antibiotic therapy and extensive surgery, which can lead to biomechanical impairments and antibiotic resistance. The use of S53P4 bioactive glass (Bonalive), a synthetic bone substitute with osteo-regenerative properties and the ability to inhibit bacterial growth by altering the local environment, is presented as a promising conservative treatment option. A case report demonstrates successful healing of digital osteomyelitis caused by MDRO using conservative surgery combined with Bonalive, resulting in infection resolution and preserved foot function over a three-year follow-up. The article suggests that integrating antibiotic therapy, conservative debridement, and bioactive glass may improve outcomes in DFO management, though further studies with larger patient groups are needed.