The association of the prothrombin A19911G single-nucleotide polymorphism and the risk of venous thromboembolism: A systematic review and meta-analysis.

This article focuses on a meta-analysis examining the association between the prothrombin A19911G single-nucleotide polymorphism and the risk of venous thromboembolism (VTE). Analyzing five high-quality studies involving 14,001 Caucasian participants, the meta-analysis found that the presence of the G allele in the prothrombin A19911G polymorphism significantly increases susceptibility to VTE across multiple genetic models. The prothrombin gene, encoding coagulation factor II, plays a critical role in blood clotting, and this polymorphism may affect prothrombin expression or function, thereby influencing thrombotic risk. The study highlights limitations including the small number of studies, focus on a single ethnicity, and observational design, and calls for larger, multicenter research to confirm these findings and explore underlying mechanisms.