JOURNAL ARTICLE

Eriodictyol and thymonin act as GPR35 agonists.

  • Published In: Bioscience, Biotechnology & Biochemistry, 2023, v. 87, n. 12. P. 1514 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Fumie Nakashima; Wei Qi Loh; Mayuka Wakabayashi; Sayako Shimomura; Hiroyuki Hattori; Masaki Kita; Asuka Inoue; Koji Uchida; Takahiro Shibata 3 of 3

Abstract

This article focuses on the identification of two polyphenolic phytochemicals, eriodictyol and thymonin, from thyme as novel agonists of G protein-coupled receptor 35 (GPR35), a receptor implicated in antioxidant and anti-inflammatory effects. Screening of 19 herb and spice extracts revealed that the ethyl acetate extract of thyme strongly activated GPR35, and subsequent activity-guided fractionation and structural analyses confirmed eriodictyol and thymonin as the active compounds with half maximal effective concentration (EC50) values of 5.48 μM and 8.41 μM, respectively. Both compounds specifically activated GPR35 in human embryonic kidney 293 cells, and their effects were inhibited by a known GPR35 antagonist, indicating direct receptor activation. These findings suggest that dietary flavonoids such as eriodictyol and thymonin may contribute to the health benefits of herbs through GPR35-mediated pathways, although further studies are needed to clarify their physiological roles.

Additional Information

  • Source:Bioscience, Biotechnology & Biochemistry. 2023/12, Vol. 87, Issue 12, p1514
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2023
  • ISSN:0916-8451
  • DOI:10.1093/bbb/zbad125
  • Accession Number:173907915
  • Copyright Statement:Copyright of Bioscience, Biotechnology & Biochemistry is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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