JOURNAL ARTICLE

Exploring the Role of Extrachromosomal Circular DNA in Human Diseases.

  • Published In: Cytogenetic & Genome Research, 2024, v. 164, n. 5/6. P. 181 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Peng, Yali; Tao, Huihui; Wang, Guoying; Wu, Mengyao; Xu, Tinatin; Wen, Chunmei; Zheng, Xuejia; Dai, Yong 3 of 3

Abstract

Background: Extrachromosomal circular DNA (eccDNA) has emerged as a central focus in molecular biology, with various types being found across species through advanced techniques, including high-throughput sequencing. This dynamic molecule exerts a significant influence on aging and immune function and plays pivotal roles in autoimmune diseases, type 2 diabetes mellitus, cancer, and genetic disorders. Summary: This comprehensive review investigates the classification, characteristics, formation processes, and multifaceted functions of eccDNA, providing an in-depth exploration of its mechanisms in diverse diseases. Key Messages: The goal of this review was to establish a robust theoretical foundation for a more comprehensive understanding of eccDNA, offering valuable insights for the development of clinical diagnostics and innovative therapeutic strategies in the context of related diseases. [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:Cytogenetic & Genome Research. 2024/12, Vol. 164, Issue 5/6, p181
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2024
  • ISSN:1424-8581
  • DOI:10.1159/000541563
  • Accession Number:183032898
  • Copyright Statement:Copyright of Cytogenetic & Genome Research is the property of Karger AG and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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