JOURNAL ARTICLE

Inherited CARD9 deficiency in a patient with both subcutaneous mucormycosis and hepatic candidiasis.

  • Published In: Journal of the European Academy of Dermatology & Venereology, 2026, v. 40, n. 1. P. e11 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Zhang, Lu; Zhang, Yi; Gong, Zhuoqing; Liu, Yiheng; Wan, Zhe; Song, Yinggai; Wang, Xiaowen; Li, Ruoyu 3 of 3

Abstract

The article focuses on a case study of a 9-year-old Chinese boy with a deficiency in caspase recruitment domain protein 9 (CARD9), who developed subcutaneous mucormycosis caused by Rhizopus microspores and hepatic candidiasis due to Candida albicans. This case is notable as it represents the first documented instance of both infections occurring in a patient with CARD9 deficiency. Genetic analysis revealed two heterozygous variants in the CARD9 gene, with one variant predicted to disrupt normal mRNA splicing. The patient was treated with a combination of intravenous amphotericin B and oral posaconazole, leading to significant clinical improvement. The findings underscore the importance of genetic screening in patients with complex fungal infections and suggest potential therapeutic strategies for managing such cases. [Extracted from the article]

Additional Information

  • Source:Journal of the European Academy of Dermatology & Venereology. 2026/01, Vol. 40, Issue 1, pe11
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2026
  • ISSN:0926-9959
  • DOI:10.1111/jdv.20709
  • Accession Number:190444398
  • Copyright Statement:Copyright of Journal of the European Academy of Dermatology & Venereology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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