Ossification and Bone Regeneration in a Canine GBR Model, Part 1: Thick vs Thin Glycated Cross-Linked Collagen Devices.

This article focuses on comparing two glycated cross-linked collagen membranes—Ossix Volumax (OV), a thick multilayered membrane, and Ossix Plus (OP), a commercially available thin-layer membrane—in guided bone regeneration (GBR) using a canine lateral ridge augmentation model. Both membranes, when used to cover alveolar bone defects grafted with a mixture of deproteinized bovine bone mineral and porcine collagen, demonstrated similar efficacy in bone regeneration, biocompatibility, and degradation profiles over 4, 12, and 24 weeks, with significantly better outcomes than untreated controls. Histological and microcomputed tomography analyses showed no significant differences between OV and OP in mineral volume, bone maturation, or alveolar ridge width, although both membranes exhibited progressive mineralization and ossification, particularly on the lingual aspect of the ridge. The study concludes that both glycated membranes serve as safe and effective occlusive barriers in GBR procedures, with no premature membrane exposures observed under the surgical conditions used.