JOURNAL ARTICLE

The effect of potassium supplementation and concomitant medications on potassium homeostasis for hospitalized patients.

  • Published In: American Journal of Health-System Pharmacy, 2024, v. 81, n. 6. P. 183 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Montepara, Courtney A; Bortmas, Mackenzie R; Cochenour, Christina J; Fleming, Maura K; Gaffey, Samantha H; McQuigg, Megan A; Parisi, Marissa K; Zimmerman, David E; Covvey, Jordan R; Nemecek, Branden D 3 of 3

Abstract

This article focuses on evaluating the impact of oral and intravenous potassium (K⁺) supplementation on serum potassium levels in adult hospitalized patients, particularly examining the influence of concomitant medications. In a retrospective study of 800 non-critically ill patients receiving potassium chloride supplementation, the median daily increase in serum K⁺ was 0.05 mEq/L per 10 mEq supplemented, which is lower than the commonly cited expectation of a 0.1 mEq/L rise. Among medications assessed, loop diuretics significantly reduced the effectiveness of potassium supplementation. The findings suggest that potassium repletion should be individualized, considering patient comorbidities and concurrent medications, and that the traditional dosing rule may overestimate serum potassium increases in general medicine ward patients.

Additional Information

  • Source:American Journal of Health-System Pharmacy. 2024/03, Vol. 81, Issue 6, p183
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2024
  • ISSN:1079-2082
  • DOI:10.1093/ajhp/zxad310
  • Accession Number:175938046
  • Copyright Statement:Copyright of American Journal of Health-System Pharmacy is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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