JOURNAL ARTICLE

Association between urinary C4d levels and disease progression in IgA nephropathy.

  • Published In: Nephrology Dialysis Transplantation, 2024, v. 39, n. 8. P. 1279 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Dong, Yaping; Wang, Zi; Guo, Weiyi; Zhu, Li; Zhou, Xujie; Shi, Sufang; Liu, Lijun; Lv, Jicheng; Zhang, Hong 3 of 3

Abstract

This article focuses on the evaluation of urinary C4d as a non-invasive biomarker for predicting renal outcomes and treatment response in immunoglobulin A nephropathy (IgAN). In a cohort of 508 biopsy-proven IgAN patients, higher urinary C4d levels were independently associated with worse kidney function, more severe proteinuria, and increased risk of kidney progression events, defined as a 50% decline in estimated glomerular filtration rate, end-stage kidney disease, or death. Additionally, elevated baseline urinary C4d predicted a poorer proteinuria response to steroids or immunosuppressive therapy. The findings suggest that urinary C4d reflects lectin pathway activation in IgAN and may serve as a useful tool for risk stratification and monitoring therapeutic response, although further validation in diverse populations is needed.

Additional Information

  • Source:Nephrology Dialysis Transplantation. 2024/08, Vol. 39, Issue 8, p1279
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2024
  • ISSN:0931-0509
  • DOI:10.1093/ndt/gfae001
  • Accession Number:178718828
  • Copyright Statement:Copyright of Nephrology Dialysis Transplantation is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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