JOURNAL ARTICLE

Rapid Determination of Preservatives in Cosmetics Using a Core–Shell Column.

  • Published In: Journal of Chromatographic Science, 2023, v. 61, n. 7. P. 637 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Tanaka, Misa; Doi, Takahiro; Takeda, Akihiro; Nakamura, Akihiko; Azuma, Yuki; Kawaguchi, Masami; Tagami, Takaomi 3 of 3

Abstract

The article focuses on the development of a rapid high-performance liquid chromatography (HPLC) method using a core–shell column for the simultaneous determination of 11 regulated preservatives in cosmetics. This method achieves complete separation of preservatives within 17 minutes—about half the time of previous methods—while maintaining high peak resolution (>2.6), strong linearity (correlation coefficients >0.9988), and satisfactory recovery rates (92.0–111.9%) with relative standard deviations (RSD) below 3.5%. The method was validated across three types of cosmetic products (lotion, oil, cream) and demonstrated reproducibility among six researchers (RSD <4.7%). It offers an efficient and reliable approach suitable for routine regulatory analysis and quality control by manufacturers and public institutions.

Additional Information

  • Source:Journal of Chromatographic Science. 2023/08, Vol. 61, Issue 7, p637
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2023
  • ISSN:0021-9665
  • DOI:10.1093/chromsci/bmac073
  • Accession Number:170047758
  • Copyright Statement:Copyright of Journal of Chromatographic Science is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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