At-home Topical Sevoflurane Added to the Conventional Analgesic Treatment for Painful leg Ulcers Greatly Improved the Analgesic Effectiveness and Reduced Opioid Consumption in a Single-Center Retrospective Comparative Study with one-Year Follow-up.

This article focuses on a retrospective cohort study evaluating the addition of at-home topical sevoflurane, a general anesthetic, to standard systemic analgesic treatment for patients with painful nonrevascularizable leg ulcers. Conducted in a Spanish Pain Clinic, the study found that patients receiving topical sevoflurane alongside usual care experienced significantly greater pain reduction over one year, as measured by the area under the curve of pain (AUC-Pain), and a marked decrease in opioid consumption compared to those receiving standard care alone. The safety profile of topical sevoflurane was acceptable, with mostly mild local adverse effects and only one patient discontinuing due to severe dermatitis. These findings suggest that topical sevoflurane may be an effective and well-tolerated adjunct analgesic therapy for chronic leg ulcer pain, warranting further investigation through randomized controlled trials.