JOURNAL ARTICLE

A novel approach: targeting virulence factors of Candida albicans with essential oil components.

  • Published In: Journal of Applied Microbiology, 2024, v. 135, n. 1. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Shaban, Abdulrahman M Abu; Darmani, Homa 3 of 3

Abstract

This article investigates the effects of various essential oil (EO) components on the virulence factors of *Candida albicans*, an opportunistic fungal pathogen. The study found that Dehydrocostus lactone, Thymol, and Carvacrol exhibited strong antifungal activity by inhibiting growth and germ tube formation, while Alpha Bisabolol showed the most potent antibiofilm effects across sub-inhibitory concentrations. Additionally, Alpha Bisabolol, Alpha Pinene, and Dehydrocostus lactone caused significant downregulation of the ACT1 gene, which encodes actin, a protein essential for fungal morphology and virulence. These findings highlight the potential of specific EO components as sustainable antifungal agents that target both viability and virulence mechanisms of *C. albicans*, warranting further in vivo and clinical research.

Additional Information

  • Source:Journal of Applied Microbiology. 2024/01, Vol. 135, Issue 1, p1
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2024
  • ISSN:1364-5072
  • DOI:10.1093/jambio/lxae012
  • Accession Number:175194319
  • Copyright Statement:Copyright of Journal of Applied Microbiology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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