JOURNAL ARTICLE

Modified intralesional aciclovir treatment in the management of recalcitrant palmoplantar and ungual warts: a case series of 14 patients.

  • Published In: Clinical & Experimental Dermatology, 2025, v. 50, n. 5. P. 1009 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Agarwal, Akash; Bansal, Parul; Madhual, Subhasree; Panda, Maitreyee 3 of 3

Abstract

This article focuses on a retrospective study evaluating the efficacy and safety of intralesional aciclovir modified with lignocaine for treating recalcitrant palmoplantar and ungual warts in 14 patients. The modified formulation maintained aciclovir's concentration at 50 mg/mL while reducing injection pain, resulting in an 82% complete response rate among 67 warts after up to five treatment sessions. Adverse effects were generally mild, including transient tenderness and occasional extravasation, with no wart recurrences observed up to four months post-treatment. The study suggests that adding lignocaine improves patient tolerability without compromising efficacy, recommending further comparative trials with other destructive treatments to establish optimal management strategies.

Additional Information

  • Source:Clinical & Experimental Dermatology. 2025/05, Vol. 50, Issue 5, p1009
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2025
  • ISSN:0307-6938
  • DOI:10.1093/ced/llae554
  • Accession Number:185321514
  • Copyright Statement:Copyright of Clinical & Experimental Dermatology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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