Investigators at IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli Zero in on Mental Disorders (Lurasidone Sub-Chronic Treatment During Adolescence Modulates Inflammatory and Inositol-Related Metabolic Pathways in the Prefrontal Cortex...).
Published In: Mental Health Weekly Digest, 2026. P. 1205 1 of 2
Database: Psychology Source 2 of 2
Abstract
This article focuses on research from Brescia, Italy, investigating the effects of lurasidone (LUR) treatment during adolescence on prenatal stress (PNS)-induced alterations in the prefrontal cortex (PFC) of adult male rats. The study found that PNS upregulated pathways related to environmental information processing and immune responses in the PFC, which were reduced following sub-chronic LUR administration during adolescence. Additionally, LUR modulated inositol-related metabolic pathways, suggesting adolescence as a critical period for early intervention in stress-related neuropsychiatric disorders. These findings highlight the potential of LUR as a preventive pharmacological strategy for mental disorders emerging from prenatal stress. [Extracted from the article]
Additional Information
- Source:Mental Health Weekly Digest. 2026/03, p1205
- Document Type:Article
- Subject Area:Health and Medicine
- Publication Date:2026
- ISSN:1543-6616
- Accession Number:192121977
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