Melanotic Neuroectodermal Tumor of Infancy in the Epididymis: A Case Report.

This article focuses on a rare case of melanotic neuroectodermal tumor of infancy (MNTI), a benign neoplasm of neural crest origin, occurring unusually in the epididymis of a 5-month-old male infant. MNTI predominantly affects the craniofacial region, with epididymal involvement reported in only about 30 cases. The tumor’s biphasic morphology, consisting of small neuroblast-like cells and larger pigmented epithelioid cells, poses diagnostic challenges, especially on frozen sections where it may be mistaken for malignancy. Radical orchiectomy was performed, and no recurrence was observed after six months without additional therapy. The report emphasizes including MNTI in the differential diagnosis of fast-growing scrotal masses in infants and highlights the importance of accurate diagnosis and surgical management due to the tumor’s potential for local recurrence and rare metastasis.