Relationship of Serum Vitamin D Levels With Diabetic Foot in Patients With Type 2 Diabetes Mellitus: A Cross-Sectional Study.

This article investigates the prevalence of 25-hydroxyvitamin D (25-OH-vitamin D) deficiency and its association with diabetic foot (DF) complications among Jordanian patients with type 2 diabetes mellitus (T2DM). In a cross-sectional study of 486 T2DM patients, 25-OH-vitamin D deficiency was found in 44.6% overall, with a higher prevalence in the DF group (57.9%) compared to those without DF (41.1%). Multivariate analysis identified lower 25-OH-vitamin D levels and higher body mass index (BMI) as independent risk factors for DF, while vitamin B12 and waist circumference appeared protective. The study highlights the potential role of vitamin D status in diabetic foot development but notes limitations including its cross-sectional design and single-center setting, suggesting further research is needed to clarify causality and underlying mechanisms.