Hyperglobulinemia predicts increased risk of mortality in primary Sjögren's syndrome: Based on a Chinese multicentre registry.

This article investigates the association between hyperglobulinemia—defined as elevated serum immunoglobulin G (IgG), A (IgA), or M (IgM)—and all-cause mortality in patients with primary Sjogren's syndrome (pSS), an autoimmune disease characterized by B-cell hyperactivity. Analyzing data from 9,527 pSS patients registered in the Chinese Rheumatism Data Centre, the study found that 44.5% had hyperglobulinemia, which was independently associated with a significantly increased risk of death (adjusted hazard ratio 1.90). The risk of mortality was positively correlated with IgG levels, and patients with both elevated IgG and IgA exhibited the highest mortality risk. These findings suggest hyperglobulinemia is a prognostic factor in pSS, although the study does not establish causality or confirm benefits of treating hyperglobulinemia.